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KMID : 0525720080130010009
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Journal of Chitin and Chitosan
2008 Volume.13 No. 1 p.9 ~ p.13
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Percutaneous Absorption of Riboflavin through Chitosan Ointments
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Oh Eun-Ha
Lee Kil-Hong
Shin Hyun-Jin
Kim Woon-Geum
Cho Seong-Kwan
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Abstract
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Among these application fields, Drug delivery system(DDS) is often used as the method of drug dosage into the epidermic
skin. We investigated characters of transdermal therapeutic system(TTS) and the skin permeability of that with applying DDS. Chitosan was selected as material of TTS. We investigated the permeation of chitosan ointment containing drug in rat skin using horizontal membrane cell model. Permeation properties of materials were investigated for water-soluble drug such as riboflavin in vitro. We used glycerin, PEG 600 and oleic acid as enhancers. Since dermis has more content water(hydration) than the stratum corneum, skin permeation rate at steady state was highly influenced when glycerin was used in water-soluble drug. The permeation rate of content enhancer and drug was found to be faster than that of content water-soluble drug only. These results showed that skin permeation rate of drug across the composite was mainly dependent on the property of ointment base and drug. Proper selection of the polymeric materials which resemble and enhance properties of the delivering drug was found to be important in controlling the skin permeation rate.
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KEYWORD
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DDS, Transdermal therapeutic system, Skin permeation rate, Chitosan
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